{"product_id":"immune-profiling-nanobody-panel","title":"Immune Profiling Nanobody Panel","description":"\u003cp\u003eThe \u003cstrong\u003eImmune Profiling Nanobody Panel\u003c\/strong\u003e is a multiplexed binder set of oligonucleotide-conjugated anti-human VHH nanobodies (~15 kDa single-domain antibodies) for simultaneous immune cell surface marker detection on the MACS Matchmaker focal molography platform.\u003c\/p\u003e\n\n\u003cp\u003eThe panel covers eight well-established leukocyte surface markers:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eCD45\u003c\/strong\u003e: pan-leukocyte (all hematopoietic cells)\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCD3ε\u003c\/strong\u003e: pan-T cell\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCD4\u003c\/strong\u003e: helper T cells\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCD8\u003c\/strong\u003e: cytotoxic T cells\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCD19\u003c\/strong\u003e: B cells\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCD56\u003c\/strong\u003e: NK cells\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCD14\u003c\/strong\u003e: monocytes\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCD7\u003c\/strong\u003e: T\/NK lineage\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003cp\u003eThis marker combination resolves the core immune cell classes: the T-cell compartment with helper and cytotoxic subset discrimination (CD3ε\/CD4\/CD8), B-cell identification (CD19), NK-cell and lymphocyte-lineage profiling (CD56\/CD7), monocyte detection (CD14), and pan-leukocyte gating (CD45).\u003c\/p\u003e\n\n\u003cp\u003eEach nanobody is conjugated to a sequence-specific oligonucleotide for DNA-directed immobilization (DDI) onto complementary capture sequences on the sensor chip surface. The nanobody format offers key advantages over conventional IgG antibodies: compact size (~15 kDa) for higher packing density on the mologram ridges, a single binding domain that eliminates Fc-mediated non-specific interactions, and a defined conjugation geometry for uniform surface orientation.\u003c\/p\u003e\n\n\u003cp\u003eThe panel runs on the \u003ca href=\"\/products\/sensor-2d-peg-oligo-oligo-16-plex-copy-copy-copy-copy\"\u003eSensor [Oligo|Oligo] 8-plex\u003c\/a\u003e for simultaneous profiling of all eight markers in a single measurement, and is compatible with complex biological matrices including whole blood, PBMCs, and serum-containing media.\u003c\/p\u003e\n\n\u003cp\u003eEach nanobody adapter is supplied pre-conjugated to the oligonucleotide sequence of choice (Seq ID 00 to Seq ID 16), so a distinct sequence can be assigned to each binder for flexible multiplexing on the sensor chip.\u003c\/p\u003e\n\n\u003ch3\u003eSpecifications\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e oligonucleotide-conjugated anti-human VHH nanobody, single binder per vial\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eVolume:\u003c\/strong\u003e 110 µL\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eConcentration:\u003c\/strong\u003e 2.6 µM\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eInjections:\u003c\/strong\u003e 10 (at 200 nM, 130 µL injection volume)\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eStorage solution:\u003c\/strong\u003e PBS-T\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003cp\u003ePlease select the desired binder and complementary oligonucleotide sequence below for your matching sensor chip.\u003c\/p\u003e\n\n\u003cp\u003e\u003cem\u003eFor research use only. Not for diagnostic or therapeutic procedures.\u003c\/em\u003e\u003c\/p\u003e","brand":"lino Biotech AG","offers":[{"title":"CD45 \/ 1","offer_id":57004524896631,"sku":"MRA-CD45-10.S01","price":218.0,"currency_code":"CHF","in_stock":true},{"title":"CD3ε \/ 2","offer_id":57004525486455,"sku":"MRA-CD3e-10.S02","price":218.0,"currency_code":"CHF","in_stock":true},{"title":"CD4 \/ 3","offer_id":57004526076279,"sku":"MRA-CD4-10.S03","price":218.0,"currency_code":"CHF","in_stock":true},{"title":"CD8 \/ 4","offer_id":57004526666103,"sku":"MRA-CD8-10.S04","price":218.0,"currency_code":"CHF","in_stock":true},{"title":"CD19 \/ 5","offer_id":57004527255927,"sku":"MRA-CD19-10.S05","price":218.0,"currency_code":"CHF","in_stock":true},{"title":"CD56 \/ 6","offer_id":57004527845751,"sku":"MRA-CD56-10.S06","price":218.0,"currency_code":"CHF","in_stock":true},{"title":"CD14 \/ 7","offer_id":57004528664951,"sku":"MRA-CD14-10.S07","price":218.0,"currency_code":"CHF","in_stock":true},{"title":"CD7 \/ 8","offer_id":57004529254775,"sku":"MRA-CD7-10.S08","price":218.0,"currency_code":"CHF","in_stock":true},{"title":"Complete 8-plex Panel \/ 1-8","offer_id":57139727663479,"sku":"MRA-ImmunePanel-10.B08","price":1526.0,"currency_code":"CHF","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0915\/3524\/5687\/files\/Immune_Profiling_Panel_8f5a5428-ce7e-44e8-9dc5-a258b671e6dc.png?v=1776064414","url":"https:\/\/shop.lino-biotech.com\/products\/immune-profiling-nanobody-panel","provider":"lino Biotech AG","version":"1.0","type":"link"}