lino Biotech AG

Polyreactivity Panel

Format: pre-conjugated ligand mix, NHS-conjugated DDI oligos
Volume: 110 µL
Concentration: 2.6 µM per ligand
Injections: 10 (at 200 nM, 130 µL injection volume)
Storage solution: PBS-T
Built-in QC: Protein A/G channel as per-injection Fc-capture control

The Polyreactivity Panel is a ready-to-use multiplexed binder set for the MACS Matchmaker focal molography platform. It quantifies non-specific binding across 8 or 16 defined liability axes in a single label-free injection on the same chip and sample as your target binding kinetics.

Two configurations are available. Essentials runs on the Sensor [Oligo|PEG] 8-plex with 8 ligands (one per major liability axis) and 8 within-chip replicates per ligand, built for the routine candidate-triage workflow at every discovery cycle. Plus runs on the Sensor [Oligo|PEG] 16-plex with 16 ligands (the Essentials set plus seven further plasma and matrix proteins and a second nucleic-acid surface) and 4 within-chip replicates per ligand, built for the in-depth developability assessment that supports lead-nomination and IND-enabling work.

Essentials, 8-plex composition

Protein A/G (Fc-capture positive control)
dsDNA (reference)
Human serum albumin (HSA)
Insulin
Human lysozyme
Aminocardiolipin
Aminoheparin
Alpha-1-acid glycoprotein (AGP / orosomucoid)

Plus, 16-plex composition

Positions 1 to 8 are identical to the Essentials 8-plex (same ligand and same DDI oligo sequence). Positions 9 to 16 add eight further liability axes exclusive to Plus.